Investigation Of In Vivo Antioxidant Activities Of Extract Karamunting (Rhodomyrtus Tomentosa(Ait.) Hassk) Fruit From Tarakan Island

Titik Ismandari

Abstract


In vivo test of karamunting fruit powder as a source of antioxidants was carried out using the MDA (malondialdehyde) test, which is a parameter commonly used to determine the extent of cellular damage caused by free radicals. In vivo testing in this study used male Wistar (Rattus norvegicus) rats aged 12 weeks with initial body weight of 216 grams to 258 grams. Prior to measurements, the samples were conditioned by oxidative stress. The purpose of this study was to determine the extent of the function of karamunting fruit extract in reducing MDA levels in the blood of experimental animals. The study consisted of treatment with karamunting fruit extract doses of 50 mg/kg, 100 mg/kg, 200 mg/kg, and 400 mg/kg per day for four weeks. The study was repeated 6 times. The research parameter is a decrease in MDA levels. Based on in vivo tests on experimental animals, karamunting fruit powder is proven to have the ability as a source of antioxidants, this is indicated by the decrease in MDA levels in experimental animals. The dose of karamunting fruit powder 200 mg/kg bw was able to reduce MDA levels from 11.315 nmol/ml to 2.54 nmol/ml. Quantity) method can save on inventory costs at the Tarakan Brewing House coffee shop by Rp. 4,591,177 for a year.

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DOI: https://doi.org/10.35334/iciksa.v0i0.78

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Jurnal J-Pen Borneo:Jurnal Ilmu Pertanian

Faculty of Agriculture, University Of Borneo Tarakan

Tarakan city, North Borneo Province, Indonesia